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They both repress hypoxia-inducible factor-1α (HIF-1α) and disturb intracellular redox homeostasis in CLL cells, as well as highly active against protected primary CLL cells [154, 155]
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Principles emerging from compartmentalization Compartmentalization reveals unifying redox principles: microdomains and relays emerge as short-range H 2 O 2 gradients are shaped and transmitted by peroxiredoxin-based cycles, allowing selective oxidation of target cysteines without elevating bulk oxidative stress (Sies 2017)
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