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Interestingly, a study of in stent-restenosis in ApoE −/− and GPx1 −/− ApoE −/− mice found that lack of GPx1 promoted vascular remodeling by mechanisms that involved reductive stress-induced proliferation of vascular smooth muscle cells [94]
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Abstract The phosphoinositide 3-kinase (PI3K)–Akt axis is one of the most frequently activated pathways and is demonstrated as a therapeutic target in Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutated colorectal cancer (CRC)
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