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More important, stress from oxygen reactions can produce mutations or loss of function in the PTEN gene that suppresses tumors even in the early phases of the condition showing increased cell numbers
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In conclusion, the accumulation of specific uremic toxins in CKD—such as indoxyl sulfate, phosphate, vanadate, and acrolein—promotes eryptosis through distinct but convergent mechanisms involving Ca 2+ dysregulation, oxidative stress, energy depletion, and kinase activation
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