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it is highly effective against antiviral-resistant HSV.[136,137] Cidofovir does not require activation by viral thymidine kinase, and both intravenous and topical forms of this drug have been successfully used to treat antiviral-resistant HSV.[138,139,140] Topical imiquimod has also been effective in persons with HIV who have antiviral-resistant HSV-2 infections, but experience is limited.[141,142] The following list includes the options for the treatment of antiviral-resistant genital HSV, but management should involve consultation with an infectious diseases specialist.[84] Foscarnet : The treatment of choice for antiviral-resistant HSV is foscarnet 40-80 mg/kg body weight IV every 8 hours until clinical resolution is attained

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