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Dihexa increased the expression of PI3K and p-AKT (Figure 5A–C)
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Gut-microbiota-derived components and metabolism (e.g., LPS and palmitate) can induce the capillarization of LSECs to promote NASH, liver fibrosis, and HCC development via the products such as mitogenic factor sphingosine-1-phosphate (S1P) and vascular cell adhesion molecule-1 (VCAM-1) [103, 104]
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