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The changes in target gene expression in the early wounds were very similar to those observed in the fibroblasts treated with L-PRF, including a decrease in COL1A1 (A1 chain of collagen 1) expression and significant increases in IL1B (interleukin 1 beta), IL6 (interleukin 6), IL8 (interleukin 8), MMP1 (matrix metalloproteinase 1), MMP3 (matrix metalloproteinase 3), FN1 (fibronectin) and TNC (tenascin C) compared to unwounded tissue
tested materials for laboratory and scientific research applications.
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