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That aside, a handful of the ingredients in Meladerm have shown promise as depigmenting agents, like alpha arbutin and azelaic acid.43 47 Additionally, niacinamide and tranexamic acid have been tested for their effects on melasma, in particular, and have shown positive outcomes.41 42 It’s worth mentioning, though, that several other ingredients, like lemon extract, pomegranate, Sepiwhite, and Symwhite 377, don’t have a lot of high-quality evidence supporting them for the treatment of hyperpigmentation

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