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Increased AGEs and AGE-RAGE interactions provide a link to cancer initiation, progression, migration, and metastasis 31,86
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Altogether, pericytes, endothelial cells, astrocytes and neurons help form the BBB by directly communicating with each other and most importantly, pericyte loss is a central event in BBB damage and derangement that contributes to neurovascular dysfunction and neuronal injury, promoting also AD pathogenesis (Sengillo et al., 2013)
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