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1 Introduction At present, depression has become a major mental illness worldwide ( Bifidobacterium ), and depressive symptoms is more directly measurable (e.g., via SCFA levels, neurotransmitter concentrations) than the vague association between “overall diet” and mood ( The gut-brain axis—a bidirectional communication network involving the central nervous system (CNS), enteric nervous system (ENS), and gut microbiota—provides a key framework for understanding “nutrition-microbiota-depression” interactions ( Bifidobacterium ) in depressed patients ( 2 Methods 2.1 Literature search strategy This review followed a systematic approach aligned with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines ( Search databases: a systematic search will be conducted across four major databases: PubMed, Web of Science Core Collection, Embase, and Cochrane Library

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This guide compares how each form works, what the research tested, the safety concerns for each route, and how to choose between them