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Pregnant or breastfeeding individuals Inositol has been studied during pregnancy (especially for gestational diabetes prevention), and meta-analyses have not identified major safety concerns at typical study doses.24 45 Even so, pregnancy and breastfeeding are situations where supplementation should be individualized, so it’s best to consult a healthcare provider before starting inositol.26 People with bipolar disorder While uncommon, several case reports suggest that inositol supplementation may trigger manic or hypomanic episodes in susceptible individuals.73 The evidence is limited, but people with bipolar disorder should consult their healthcare provider before taking inositol, particularly if they have a history of mania or are taking mood-stabilizing medications
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