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While senescence acts as a protective mechanism against tumorigenesis, the accumulation of senescent cells and their inflammatory SASP can promote tumor progression.53 Combination therapies that target senescent cells in the tumor microenvironment and modulate the SASP could offer new therapeutic options in cancer treatment, potentially inhibiting tumor growth while enhancing the efficacy of existing therapies like chemotherapy and immunotherapy.194,217 Preclinical Evidence Supporting Combination Therapies In preclinical animal models, the combination of senolytic and senomorphic agents has shown promising results