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Similarly, the length of DNA replication termination sites (TSs) tended to be shorter in leukemia cells expressing ATF4-targeting shRNAs compared to controls in both NOMO-1 (shNT mean = 84043 bp, shATF4-1 mean = 68504 bp, shATF4-2 mean = 74353 bp) and OCI-AML3 cells (shNT mean = 85989 bp, shATF4-2 mean = 75397 bp) (Fig
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Thus, the cytotoxic effects due to increased ROS production by pyocyanin ultimately lead to cell death followed by cell lysis (O'Malley et al
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