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Glutaredoxin (Grx), a GSH-dependent disulfide oxidoreductase, catalyzes dithiol reactions, reducing GSH-protein mixed disulfides in a coupled system with GR and NADPH as an electron donor (58, 72)
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It was originally developed as an anti-obesity drug candidate because early research suggested it could stimulate lipolysis (fat breakdown) and reduce lipogenesis (fat formation) without the typical growth-promoting or IGF-1–raising effects of full HGH
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