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Broad gene-mapping work led by Pickart and colleagues reported modulation of thousands of genes, with roughly a third of human gene patterns shifting toward expression states associated with younger or healthier tissue

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Equivalent doses of morphine sulfate and diamorphine hydrochloride given over 24 hours These equivalences are approximate only and should be adjusted according to response ORAL MORPHINE PARENTERAL MORPHINE PARENTERAL DIAMORPHINE Oral morphine sulfate over 24 hours Subcutaneous infusion of morphine sulfate over 24 hours Subcutaneous infusion of diamorphine hydrochloride over 24 hours 30 mg 60 mg 90 mg 120 mg 180 mg 240 mg 360 mg 480 mg 600 mg 780 mg 960 mg 1200 mg 15 mg 30 mg 45 mg 60 mg 90 mg 120 mg 180 mg 240 mg 300 mg 390 mg 480 mg 600 mg 10 mg 20 mg 30 mg 40 mg 60 mg 80 mg 120 mg 160 mg 200 mg 260 mg 320 mg 400 mg If breakthrough pain occurs give a subcutaneous (preferable) or intramuscular injection equivalent to one-tenth to one-sixth of the total 24-hour subcutaneous infusion dose