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Structural mechanism of TOPBP1 activating the ATR–ATRIP replication checkpoint kinase - PMC
It has been discussed in literature as a model for studying copper coordination, peptide-metal interaction, extracellular matrix signaling, and tissue-remodeling biology
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Among these genes, nuclear factor-erythroid 2 related factor 2 (Nrf2) was identified as the top target
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