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Accordingly, In AD patients, the protein degradation system in astrocytes is boosted, manifested as increased markers, such as cathepsins B, beclin-1, HSPB1, E3 ubiquitin-protein ligases, and calpain (Viejo et al., 2022) It seems that astrocyte in the vicinity of Aβ plaque exhibit activated autophagy and phagocytic activity
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