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In podocyte models of diabetic kidney disease, PHGDH deficiency exacerbates cellular damage (e.g., cytoskeleton disruption) and significantly promotes ferroptosis [92]
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Rather than the presumed rate limiting GA20ox enzyme step, both early biosynthetic steps and the final Gibberellin 3-oxidase (GA3ox) catalysed step were locally rate limiting in the elongation zone, the site of high gibberellin accumulation in Arabidopsis roots (Rizza et al., Reference Rizza, Tang, Stanley, Grossmann, Owen, Band and Jones2021)
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