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Here, we demonstrated that metal-saturated SOD1 WT (holo-SOD1 WT ) and a familial ALS (fALS) catalytically active SOD1 mutant, SOD1 G93A , are capable, under defined metabolic circumstances, to generate cytotoxic quantities of H 2 O 2 through cysteine (CSH)/glutathione (GSH) redox short-circuit
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In the gastrointestinal tract, vitamin B12 protein complexes are degraded by pepsin and the acidic environment of the stomach [17,18,40]
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