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Peroxisome–mitochondria axis For the peroxisome–mitochondria axis, the rationale is that peroxisomal β-oxidation is a major H 2 O 2 source (via acyl-CoA oxidases and other flavoproteins) and peroxiporins allow H 2 O 2 to exit the organelle and coordinate with cytosolic and mitochondrial pathways—so when flux outstrips buffering, lipid-peroxide pressure rises and spills into neighbouring compartments (Lismont et al
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doi: 10.1038/s41392-022-01229-y 20 CircuM
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