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JCI - Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons
Fifth, disrupted mitochondrial dynamics refers to imbalance between fission (mediated by Drp1) and fusion (mediated by Mfn1/2 and OPA1), leading to mitochondrial fragmentation and functional decline (Sulkshane et al., 2021)
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Much of our knowledge concerning specific enzymes and processes involved in phase I APAP metabolism has come from rodent studies, with limited corroboration in human models
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