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Further, AngII binding at the AT 1 receptor increased DA neuron degeneration initiated by subthreshold doses of DA neurotoxins by stimulating intra-neuronal levels of Reactive Oxygen Species (ROS) and neuroinflammation by activation of microglial NADPH oxidase [199,201,227,228]
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Alzheimer’s Disease (AD) AD is pathologically characterized by amyloid β (Aβ) deposition and neurofibrillary tangles in the brain, and loss of synaptic connections in specific areas of the brain [173]
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