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The therapeutics available for such pain management include serotonin noradrenaline reuptake inhibitors (duloxetine), selective serotonin reuptake inhibitors (paroxetine and citalopram), tricyclic antidepressants (amitriptyline, nortriptyline and imipramine), calcium channel α2δ agonists, anticonvulsants (gabapentin and pregabalin), opioids (morphine, oxycodone, fentanyl, buprenorphine and methadone), N -methyl-d-aspartate (NMDA) receptor antagonists (ketamine and dextromethorphan), α-lipoic acid, NO donors and topical adjuvants (e.g., capsaicin and lidocaine)
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