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However, seasonal allergies and food allergies can throw a wrench in the most well-planned routines: **Physical Discomfort: **Allergies can result in fatigue, runny noses, and watery eyes - hardly the condition one wants to be in when lifting heavy weights

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Hippocampal mitochondria of 18-month-old mice with adult-induced liver IGF-1 deficiency (iLID) (at 5 months of age) showed lower level of OXPHOS and increased mitochondrial uncoupling, lower level of ATP production, and increased level of oxidative damage, as compared to aged controls [39]