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Outcome indicators: studies reporting any association related to the pathway “nutrients [e.g., dietary fiber, omega-3 polyunsaturated fatty acids (PUFAs)] → intestinal inflammation → depression,” including but not limited to intestinal inflammation markers [e.g., interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α)], depression assessment scores [e.g., Beck Depression Inventory-II (BDI-II), Patient Health Questionnaire-9 (PHQ-9)], and changes in gut microbiota composition

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Many patients get significant relief — sometimes lasting months, sometimes permanently — and the response to a cortisone injection is itself diagnostically useful (a strong response confirms that the median nerve is the problem)