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preferred antibodies or antigen-binding fragments for carrying out various embodiments of the disclosure comprise an antibody or antigen-binding fragment comprising six complementarity determining regions (CDRs), CDRH1 , CDRH2, CDRH3, CDRL1 , CDRL2, or CDRL3, or combinations thereof, wherein CDRH1 comprises SEQ ID NO: 234, CDRH2 comprises SEQ ID NO: 235, CDRH3 comprises SEQ ID No: 236, CDRL1 comprises SEQ ID NO: 237, CDRL2 comprises EVS, and CDRL3 comprises any one of SEQ ID Nos: 239 or 240, as defined by the Chothia numbering system

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[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Recombinant porphobilinogen deaminase targeted to the liver corrects enzymopenia in a mouse model of acute intermittent porphyria