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‍ Symptoms associated with Mast Cell Activation Syndrome headaches brain fog low blood pressure fatigue skin rashes/hives swelling/edema flushing itching abdominal pain nausea/vomiting diarrhea wheezing shortness of breath heart palpitations anxiety, difficulty concentrating (See Keith Berndtson’s ( slide.) ‍ Diseases Associated with Mast Cell Activation Syndrome Allergies and Asthma Autism Autoimmune diseases (Hashimoto’s thyroiditis, systemic lupus, multiple sclerosis, bullous pemphigoid, rheumatoid arthritis and others) Celiac Disease Chronic Fatigue Syndrome Chronic inflammatory response syndrome (CIRS) Eczema Eosinophilic Esophagitis Fibromyalgia Food Allergy and Intolerances Gastroesophageal reflux (GERD) Infertility (mast cells in endometrium may contribute to endometriosis) Interstitial Cystitis Irritable Bowel Syndrome (IBS) Migraine Headaches Mood disorders – anxiety, depression, and insomnia Multiple Chemical Sensitivities POTS (postural orthostatic tachycardia syndrome) Virtually, every organ is affected by the MCs upregulation