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Common features between targets across diseases permit the repositioning of already developed drugs effective for one disease to be assessed in another, as epitomized by exendin-4 – an efficacious drug in type 2 diabetes mellitus [184-186, 188] presently being assessed in early efficacy studies in PD and AD
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1.2.2 Meeting the challenge with a simple solution It is here that we have focused on what it takes to provide a mucus-penetrating niclosamide solution rather than microparticulate material that is simply trapped at the mucus surface, and then excreted as the mucin is replaced (every 15-20 minutes (47))
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