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The positive effects are related to the elimination of the S protein, which could act agonistically or antagonistically on ACE2 functions
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The JAK1/STAT3 pathway was implicated in this mechanism, and the beneficial effects of melatonin were partially diminished when a JAK1 inhibitor was administered, indicating the importance of this pathway in mediating the effects of melatonin (Shukla et al., 2017)
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