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Initial results from early randomized placebo-controlled studies such as the Women's Health Initiative suggesting that HRT increased the risk of coronary heart disease and breast cancer across the board in postmenopausal women were inappropriately interpreted and communicated with the public, leading to sharp declines in HRT prescriptions (115, 116)

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one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy